药化助理总监/副总监/总监

Job description

药化策略与分子设计

• 主导靶点药化可行性评估及从Hit到PCC的发现与优化全流程，基于SAR、DMPK及安全性数据迭代分子结构，确定临床前候选化合物。

项目全流程管理

• 制定研发计划与里程碑，统筹推进从立项到IND申报支持的全流程，负责合成路线规划、关键节点决策及风险管控。

跨部门协同与资源管理

• 联动生物、DMPK、药理、CMC及专利等部门推动项目交付；内外部CRO的进度跟踪、数据审阅与质量把控。

技术指导与团队建设

• 为组内成员提供实验设计、数据分析及问题解决的技术指导，组织技术分享与培训，营造开放高效的科研氛围，提升团队整体药化设计水平与凝聚力。

学历专业

• 药物化学、有机化学或相关专业博士学历。

工作经验

• 5年以上工业界新药研发经验，其中不少于3年作为药化项目负责人，有成功推进至PCC经验者优先。

技术能力

• 精通药物化学设计原则，能综合平衡活性、选择性、成药性与可开发性。

管理能力

• 具备优秀的跨学科沟通、资源协调、团队建设与人员培养能力。

其他

• 英文听说读写流利，有海外教育/工作背景优先。

Job Title

Assistant Director, Medicinal Chemistry Position Level: L40 Assistant Director, leading a team of 3–5 people Job Responsibilities:

Medicinal Chemistry Strategy and Molecular Design

• Lead target druggability assessment and the full discovery and optimization process from Hit to PCC; iterate molecular structures based on SAR, DMPK, and safety data to identify preclinical candidate compounds.

Full-Cycle Project Management

• Develop research plans to ensure milestones delivery; coordinate and advance the full process from project initiation to IND filing support; responsible for synthetic route planning, key milestone decision-making, and risk management.

Cross-Functional Collaboration and Resource Management

• Collaborate with biology, DMPK, pharmacology, CMC, and intellectual property departments to drive project delivery; track progress, review data, and ensure quality control for internal and external CROs.

Technical Guidance and Team Building

• Provide technical guidance to team members in experimental design, data analysis, and problem-solving; organize technical sharing and training; foster an open and efficient research atmosphere; and enhance the team's overall medicinal chemistry design capabilities and cohesion.

Education and Major

• PhD in medicinal chemistry, organic chemistry, or a related field.

Work Experience

• More than 5 years of industry experience in new drug R&D, including no less than 3 years as a medicinal chemistry project leader; experience successfully advancing a project to PCC is preferred.

Technical Capabilities

• Proficient in medicinal chemistry design principles; able to comprehensively balance potency, selectivity, drug-likeness, and developability.

Management Capabilities

• Excellent cross-disciplinary communication, resource coordination, team building, and personnel development skills.

Other

• Fluent in English listening, speaking, reading, and writing; overseas education/work background preferred.