[Skip to main content](#main-content) [OpenNash Jobs](https://jobs.opennash.com/) [Hiring report](/reports/hiring/) · [All Stryker jobs](https://jobs.opennash.com/companies/stryker/) · [Search jobs](/search/) Stryker · Irvine, California # Principal Engineer- Advanced Operations Irvine, California Senior individual contributor $135,700 - $226,200 Operations Listed on Stryker’s official careers site. Listed as of October 18, 2026. Check that it is still open and apply there. [Apply on Stryker’s careers site →](https://stryker.wd1.myworkdayjobs.com/StrykerCareers/job/Irvine-California/Principal-Engineer--Advanced-Operationa_R571178) [OpenNash Jobs](https://jobs.opennash.com/) / [Stryker](https://jobs.opennash.com/companies/stryker/) / Principal Engineer- Advanced Operations ## Job description ### Work Flexibility Onsite The Principal Advanced Operations Engineer - Technical Lead is a senior technical leader responsible for driving manufacturing excellence, process development, technology transfer, and operational readiness for new product launches. As the primary manufacturing and operations engineering authority within R&D, this role leads cross-functional initiatives to enhance manufacturability, improve operational performance, and accelerate commercialization. The position requires expertise in manufacturing engineering, process validation, lean manufacturing, automation, quality systems, and project leadership. ### Key Responsibilities Serve as the technical lead for advanced manufacturing and operations engineering initiatives supporting new product development, implementation, and commercialization. Provide strategic direction for manufacturing process development, optimization, scale-up, operational readiness, and technology transfer to production. Partner with R&D throughout the product development lifecycle to ensure manufacturability and scalability and drive engineering best practices through Design for Manufacturing (DFM) and Design for Assembly (DFA). Lead continuous improvement initiatives focused on safety, quality, delivery, and cost performance. Lead equipment qualification and process validation activities, including IQ/OQ/PQ execution. Collaborate with Quality, Supply Chain, Manufacturing, Regulatory Affairs, and R&D to deliver successful product launches and process implementations. Lead multidisciplinary project teams, influence organizational stakeholders, and drive alignment on technical and operational decisions. Provide technical expertise in lean manufacturing, Six Sigma, advanced manufacturing processes, automation, and process validation methodologies. ### Qualifications Required: Bachelor's degree in Engineering or related field. 8+ years of progressive experience in manufacturing engineering, operations, or new product implementation. 5+ years leading complex technical projects and cross-functional teams. ### Preferred Master's degree. Experience in regulated industries. Experience with process validation, equipment qualification, lean manufacturing, and continuous improvement methodologies. Experience influencing both leaders and individual contributors cross functionally. ### United States of America Pay Ranges US15: $135,700 - $226,200 USD Annual Travel Percentage: 20% Stryker Corporation is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, or protected veteran status. Stryker is an EO employer – M/F/Veteran/Disability. Stryker Corporation will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information. ## At a glance - Posted by the employer: Not stated - First seen by OpenNash: Oct 11, 2026 - Last checked: Oct 18, 2026 - Listed for: 7 days - Location: Irvine, California - Pay: $135,700 - $226,200[Apply on Stryker’s careers site →](https://stryker.wd1.myworkdayjobs.com/StrykerCareers/job/Irvine-California/Principal-Engineer--Advanced-Operationa_R571178) ## More jobs at Stryker ### [Process Development Engineer](https://jobs.opennash.com/companies/stryker/jobs/9e7e6944a3c019194385/) Irvine, California ### [Senior Engineer, Continuous Improvement](https://jobs.opennash.com/companies/stryker/jobs/8df4de28ee8af31d34f9/) Irvine, California ### [Account Manager - North Orange County - Peripheral Vascular](https://jobs.opennash.com/companies/stryker/jobs/d6f48459542129a4cb39/) Irvine, California ### [Assembler I - 2nd Shift - $23.30/hr + $1.50/hr Shift Differential](https://jobs.opennash.com/companies/stryker/jobs/78f47ae12738e30d7985/) Irvine, California ### [Assembler II - 2nd Shift - $24.80/hr + $1.50/hr Shift Differential](https://jobs.opennash.com/companies/stryker/jobs/bc578ff504e79498b38c/) Irvine, California ## Similar jobs at other companies ### [Principal Security Operations Engineer](https://jobs.opennash.com/companies/microsoft/jobs/e6c5b808a62328b4801e/) Microsoft · United States, Washington, Redmond ### [Principal Network Operations Engineer / IT Operations Specialist (US)](https://jobs.opennash.com/companies/td-bank-group/jobs/7046ef8aa3f9b051b939/) TD Bank Group · Mount Laurel, New Jersey ### [Advanced Brokerage Operations Professional](https://jobs.opennash.com/companies/thrivent-financial/jobs/4e61328638c7fb9ad0cd/) Thrivent Financial · United States ### [Principal Quality Engineer – Design & Operations Quality](https://jobs.opennash.com/companies/bae-systems/jobs/4a65b5bcdbcdbf60b5aa/) BAE Systems · Maple Grove, Minnesota, United States ### [Senior/Staff/Principal/MTS Engineer, Etch - Procurement and Operations Central Team Advanced Development](https://jobs.opennash.com/companies/micron-technology/jobs/69afcd8a1aaf68e756a4/) Micron Technology · Boise, ID - Main Site OpenNash lists jobs from employers’ own careers sites and does not handle applications. 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