[Skip to main content](#main-content) [ OpenNash ](https://opennash.com/) / [Jobs](https://jobs.opennash.com/) [ 01 Search jobs](https://jobs.opennash.com/search/)[ 02 Companies](https://jobs.opennash.com/explore/)[ 03 Hiring report](https://jobs.opennash.com/reports/hiring/)[ 04 AI assistants](https://jobs.opennash.com/connect/)[ 05 How it works](https://jobs.opennash.com/methodology/) Roche Holding · Multiple locations # Principal Quantitative Scientist (Real World Evidence) Multiple locations Full-time Senior individual contributor Research & Science Listed on Roche Holding’s official careers site. Posted November 3, 2026. Check that it is still open and apply there. [Apply on Roche Holding’s careers site →](https://roche.wd3.myworkdayjobs.com/roche-ext/job/Indianapolis/Principal-Quantitative-Scientist_202610-125801-1) [OpenNash Jobs](https://jobs.opennash.com/) / [Roche Holding](https://jobs.opennash.com/companies/roche-holding/) / Principal Quantitative Scientist (Real World Evidence) ## Job description At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position Roche Diagnostics has built a new strategic area – Roche Information Solutions (RIS) - charged with creating a modern portfolio of decision support software products and generating insights that change the way patients are cared for. Our challenge is to bring together complex diagnostic and treatment data from medical devices and IT systems and intelligently process and present this data to clinicians, researchers, and caregivers to improve research outcomes and patient care by offering a suite of Clinical Decision Support (CDS) solutions. This role requires 3 days of being on-site in Indianapolis. The Opportunity As a Senior Principal Quantitative Scientist, you will act as a leading scientific authority for Real-World Data (RWD), driving evidence generation that fundamentally shapes the development and adoption of our digital health, and IVD portfolio. This is a high-impact, independent, and externally facing role requiring scientific leadership, deep expertise, and the ability to influence critical business, regulatory, and long-term strategic decisions. Your work will involve leveraging diverse data types, including EHR, claims, omics, and digital health data. ### Key Responsibilities Include: RWD Strategy & Execution (End-to-End Leadership) Drive the conceptualization, planning, execution, and reporting of complex, advanced RWD studies using various research and commercial healthcare databases. Develop RWD study protocols and independently lead complex analyses to support the evidence needs of the IVD and digital health portfolio, across multiple therapeutic areas. Ensure the design, execution, and presentation of RWE adhere to the highest scientific and methodological standards. Strategic Influence & Adoption (Thought Leadership) - Act as the go-to RWD leader, working closely with cross-functional stakeholders such as Product - Leads and Medical Affairs to ensure RWD projects directly support commercial, market access, and regulatory needs. Champion RWD's use to supplement clinical evidence and actively identify and drive implementation of opportunities where RWD can serve as the primary evidence mechanism to achieve regulatory and reimbursement objectives. Represent Roche as a recognized subject matter expert with external partners (KOLs, academic institutions, healthcare authorities), leading joint publications on study design and fostering strong relationships to explore new data assets and analytical methodologies. Expertise & Mentorship Serve as the internal authority on RWD sources, epidemiology, and state-of-the-art methodologies, setting best practices for the entire RWD function. Proactively drive innovation by defining and implementing enhanced ways of working (processes, methods, technology) and proactively sharing learnings with peers. Routinely mentor junior colleagues and act as an influential subject matter expert across the organization. ### Who You Are You hold a PhD (preferred) OR Master’s Degree in a Quantitative Science field (e.g. Pharmacoepidemiology, Epidemiology, RWD Biostatistics, Pharmacoeconomics, Health Economic and Outcomes Research, or related). 7+ years of directly related (industry, consulting, or other relevant) experience, demonstrating increasing levels of responsibility and independent scientific leadership. Exceptional track record of utilizing RWD to support successful and complex regulatory submissions. Deep mastery of epidemiology and causal inference methodologies is required, including expertise in debating and defending methods to external regulatory and HTA bodies. Strong programming experience with R, Python, SQL and/or other quantitative software. Strong experience in using diverse RWD sources to generate insights and evidence. ### Additional Skills Expertise in RWD & Epidemiology: Proven hands-on experience in designing, implementing, and reporting high-impact RWD studies, with recognized expertise in advanced epidemiology and a passion for making a difference in healthcare. ### Strategic & Regulatory Acumen A comprehensive and forward-looking understanding of regulatory guidelines and an ability to use RWD to proactively influence national and international reimbursement and clinical guidelines. ### Project & People Leadership Demonstrated ability to lead projects of significant scope and complexity. You are a recognized team leader with experience mentoring and guiding senior team members and possess a resilient, can-do attitude. ### Communication & Collaboration Excellent communication and collaboration skills, including the proven ability to negotiate and influence senior leaders across the organization and with external stakeholders without formal authority. ### Problem-Solving & Mindset A data-savvy, creative, and resilient problem solver with a sense of enterprise-wide ownership and attention to detail. You are eager to learn and expand your scientific expertise as a dependable team player and critical thought partner. Must be willing to work onsite in Indianapolis. Relocation benefits are not available for this position. The expected salary range for this position based on the primary location of Indianapolis, IN is between $124,500 and $231,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. ### Benefits Where pay transparency applies, details are provided based on the primary posting location. For this role, the primary location is Indianapolis. If you are interested in additional locations where the role may be available, we will provide the relevant compensation details later in the hiring process. Who we are A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact. Let’s build a healthier future, together. Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants. ## At a glance - Posted by the employer: Nov 3, 2026 - First seen by OpenNash: Oct 25, 2026 - Last checked: Nov 8, 2026 - Listed for: 14 days - Location: Multiple locations - Employment type: Full-time[Apply on Roche Holding’s careers site →](https://roche.wd3.myworkdayjobs.com/roche-ext/job/Indianapolis/Principal-Quantitative-Scientist_202610-125801-1) ## Hiring at Roche Holding - Open jobs: 1,258 - New in the last 7 days: 216 - Tracked since: Jul 16, 2026 [All Roche Holding jobs](https://jobs.opennash.com/companies/roche-holding/) · [Weekly hiring report](/reports/hiring/) ## More jobs at Roche Holding ### [Principal Scientist - Discovery Oncology](https://jobs.opennash.com/companies/roche-holding/jobs/e5fbbe9f849f5c1b582f/) Basel ### [R&D Associate](https://jobs.opennash.com/companies/roche-holding/jobs/dfda90a48055c0cd3076/) Sant Cugat del Vallès ### [RNA Biology Associate in oligonucleotide screening](https://jobs.opennash.com/companies/roche-holding/jobs/ca8f7576a8fdef791276/) Basel ### [RWD Scientist](https://jobs.opennash.com/companies/roche-holding/jobs/e0c9bf2602309a9f6e82/) Shanghai ### [Scientist / Principal Associate, In Vitro Metabolism & DDI Assessment](https://jobs.opennash.com/companies/roche-holding/jobs/371433c87bc2e0bd279a/) Shanghai ## Similar jobs at other companies ### [Credit Model Development Quantitative Lead - Commercial Real Estate Portfolio(Hybrid)](https://jobs.opennash.com/companies/mt-bank/jobs/45ed029bf93d6621360f/) M&T Bank ### [Senior Quantitative Analyst](https://jobs.opennash.com/companies/manulife/jobs/2d99bc3610e4190928a9/) Manulife ### [Staff Quantitative Scientist](https://jobs.opennash.com/companies/alphabet/jobs/a30b79439d0664a933e7/) Alphabet ### [Quantitative Trading & Research, Quantitative Developer - Associate](https://jobs.opennash.com/companies/jpmorganchase/jobs/eb36db676ff097d21f26/) JPMorganChase · Singapore ### [Quantitative Trading & Research - EM Rates Quantitative Trading](https://jobs.opennash.com/companies/jpmorganchase/jobs/747b7c9650e30895db73/) JPMorganChase · Sao Paulo, SP, Brazil [Research & Science jobs](/functions/research-science/) OpenNash lists jobs from employers’ own careers sites and does not handle applications. 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