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Revolution Medicines · Remote

# Senior Director, Global Commercial Development

Remote Remote Director $232,000 — $290,000 Sales 

Listed on Revolution Medicines’s official careers site. Posted November 6, 2026. Check that it is still open and apply there.
[Apply on Revolution Medicines’s careers site →](https://www.revmed.com/careers-list/?gh_jid=8197993003)

[OpenNash Jobs](https://jobs.opennash.com/) / [Revolution Medicines](https://jobs.opennash.com/companies/revolution-medicines/) / Senior Director, Global Commercial Development

## Job description

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

### The Opportunity

Reporting to the Executive Director, Global Commercial Development – Pancreatic Cancer, this role will lead global commercial strategy and lifecycle development for the pancreatic cancer portfolio. This job description is across numerous positions, including daraxonrasib and zoldonrasib and future pipeline candidates, supporting opportunities in first-line metastatic, locally advanced, perioperative, and adjuvant disease, as well as future indications.

This leader will translate evolving clinical evidence, patient and biomarker insights, and competitive dynamics into integrated global commercial strategies, portfolio investment recommendations, and stage-appropriate launch readiness. The role requires strong cross-functional leadership and close alignment with existing asset and indication teams.

Specifically, you will be responsible for: Own integrated pancreatic portfolio strategy: Lead global commercial development across therapeutic and pancreatic cancer settings; connect indication strategies to overall portfolio value.

### Guide indication and lifecycle prioritization

Evaluate clinical and commercial opportunities, unmet need, competitive differentiation, treatment sequencing, and investment trade-offs; present clear recommendations for development and governance decisions.

### Build treatment-setting strategies

Develop differentiated commercial hypotheses for first-line treatment, locally advanced disease, surgical/perioperative pathways, and adjuvant therapy, recognizing distinct patient journeys, customers, and evidence requirements.

### Integrate asset and combination positioning

Partner with relevant product teams to shape complementary daraxonrasib and zoldonrasib strategies, including biomarker-defined populations, potential combination approaches, and implications of future portfolio evolution.

### Lead patient and market forecasting

Develop global epidemiology, treatment-flow and patient-segmentation models, revenue scenarios, sensitivity analyses, and commercial value assessments across the continuum of pancreatic cancer care.

### Shape clinical development through a commercial lens

Collaborate with Clinical Development, Medical Affairs, HEOR, and Market Access on target populations, meaningful endpoints, duration of therapy, standards of care, and evidence needed for future adoption.

### Advance biomarker and patient-identification strategy

Work with Precision Medicine and Diagnostics on RAS/KRAS testing, KRAS G12D-defined populations, laboratory and referral workflows, accessibility, and the commercial implications of molecularly guided care.

### Connect the multidisciplinary ecosystem

Build a unified commercial understanding of oncologists, pancreatic surgeons, gastroenterologists, radiologists, pathologists, multidisciplinary tumor boards, academic centers, and community settings, in partnership with Medical Affairs and existing engagement teams.

### Align with cross-portfolio leaders

Coordinate with established first-line/metastatic teams, regional affiliates, and global brand teams to share insights and ensure best in class launches.

### Prepare for future launches and expansions

Develop stage-gated global commercialization frameworks, value propositions, brand positioning, affiliate readiness, access and customer-pathway assumptions, and launch scenarios for the U.S. and global markets.

### Track market evolution and performance

Monitor scientific milestones, competing programs, diagnostic adoption, treatment patterns, and commercial assumptions; adjust strategic plans and forecasts as evidence and investment decisions evolve.

### Lead execution and influence

Guide cross-functional working teams, agencies, market research and analytics partners; communicate succinctly with senior leaders and governance forums and apply innovative digital and data-driven approaches. Up to 40% of travel required.

### Required Skills, Experience and Education

Bachelor’s degree with at least 15 years, or advanced degree with at least 8 years, of progressive commercial experience in a biotechnology and/or pharmaceutical company, including strategic marketing and ideally sales. Proven success developing global oncology commercial strategies across products, indications, or stages of disease and influencing complex cross-functional product teams. Demonstrated ability to develop patient and revenue forecasts, interpret market and clinical insights, and evaluate strategic trade-offs that inform portfolio investment decisions.

Strong leadership, ability to build high-performing teams and partnerships, and ability to influence without direct authority. Excellent organizational and prioritization skills and the ability to deliver high-quality strategic work under evolving timelines. Strong clinical and scientific acumen; ability to translate emerging clinical evidence, trial design, and oncology treatment pathways into commercial implications.

Excellent executive communication, presentation, and external stakeholder engagement skills. Entrepreneurial mindset, comfort with ambiguity, and commitment to improving outcomes for people with cancer.

### Preferred Skills

Experience in pancreatic or other gastrointestinal cancers, including first-line metastatic and earlier-stage treatment settings. Experience with precision oncology, KRAS/RAS-targeted medicines, molecular testing, or biomarker-defined patient populations. Experience developing global commercial strategies for oncology launches, indication expansion, or lifecycle management. Familiarity with oncology care pathways and patient journeys in pancreatic cancer.

Experience working in a rapidly growing biotechnology company and partnering with global and regional commercial organizations. #LI-JW1 #LI-Remote The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in.

Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone.

We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. Base Pay Salary Range $232,000 — $290,000 USD We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.

Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address. If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to careers@revmed.com so we can share these impersonations with our IT team for tracking and awareness.

## At a glance
- Posted by the employer: Nov 6, 2026
- First seen by OpenNash: Nov 8, 2026
- Last checked: Nov 8, 2026
- Listed for: 2 days
- Location: Remote
- Work arrangement: Remote
- Pay: $232,000 — $290,000[Apply on Revolution Medicines’s careers site →](https://www.revmed.com/careers-list/?gh_jid=8197993003)

## Hiring at Revolution Medicines
- Open jobs: 323
- New in the last 7 days: After two weekly collections
- Tracked since: Jul 10, 2026

[All Revolution Medicines jobs](https://jobs.opennash.com/companies/revolution-medicines/) · [Weekly hiring report](/reports/hiring/)

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