[Skip to main content](#main-content) [OpenNash Jobs](https://jobs.opennash.com/) [Hiring report](/reports/hiring/) · [All Novartis jobs](https://jobs.opennash.com/companies/novartis/) · [Search jobs](/search/) Novartis # Sr Manager Automation Gtx Lead On-site Manager or lead $211,900 annually Listed on Novartis’s official careers site. Listed as of October 18, 2026. Check that it is still open and apply there. [Apply on Novartis’s careers site →](https://www.novartis.com/careers/career-search/job/details/req-10086624-sr-manager-automation-gtx-lead) [OpenNash Jobs](https://jobs.opennash.com/) / [Novartis](https://jobs.opennash.com/companies/novartis/) / Sr Manager Automation Gtx Lead ## Job description Join Novartis and play a pivotal role in advancing next-generation gene therapies through innovative automation leadership. As Sr. Manager, Automation – GTx Lead, you will lead a high-performing team responsible for critical IT/OT and automation systems that enable reliable, compliant, and efficient manufacturing operations. This is an opportunity to shape automation strategy, drive continuous improvement, and influence the future of advanced therapies while collaborating across Engineering, Manufacturing, Quality, and Technical Operations in a fast-paced GMP environment. ## Responsibilities ### Location This position will be located in Durham, NC and will be an onsite role.Novartis is unable to offer relocation support for this role: please only apply if this location is accessible for you. ### Key Responsibilities Lead the design, implementation, maintenance, and support of manufacturing automation systems and process equipment.Drive continuous improvement initiatives to enhance automation performance, reliability, and innovation.Execute site automation strategies aligned with global Novartis standards and best practices.Own and oversee computerized systems supporting critical manufacturing processes.Lead, mentor, and develop a team of automation engineers supporting 24/7 operations.Establish and improve KPIs to maximize system reliability, availability, and operational excellence.Own change controls and CAPAs to drive compliance and continuous improvement.Lead automation-related deviation investigations and provide SME expertise for root cause analysis.Serve as the automation SME during regulatory inspections and internal or external audits.Partner with Engineering, Manufacturing, Quality, and Technical Operations to support new product introductions and site initiatives. ### Essential Requirements Bachelor's degree in Engineering or a related field with 9+ years of experience across IT/OT and automation platforms.Strong expertise with DCS, PLC, SCADA, MES, Historian systems, and process equipment supporting drug substance and drug product manufacturing.Proven experience designing, operating, modifying, maintaining, and retiring computerized systems in a regulated manufacturing environment.Demonstrated success leading technical teams and supporting complex 24/7 manufacturing operations.Ability to collaborate effectively across Quality Engineering, Quality Assurance, Validation, Engineering, and Manufacturing functions.Strong problem-solving, planning, decision-making, and communication skills.Knowledge of FDA regulations, cGMP requirements, and health, safety, and environmental standards.Proficiency with Microsoft Office, CMMS, Building Management Systems, and related digital tools. ### Novartis Compensation and Benefit Summary The salary for this position is expected to range between $114,100 and $211,900 annuallyThe final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.#LI-Onsite ## At a glance - Posted by the employer: Not stated - First seen by OpenNash: Oct 11, 2026 - Last checked: Oct 18, 2026 - Listed for: 7 days - Work arrangement: On-site - Pay: $211,900 annually[Apply on Novartis’s careers site →](https://www.novartis.com/careers/career-search/job/details/req-10086624-sr-manager-automation-gtx-lead) ## More jobs at Novartis ### [Lehre Labortechnik Mfd](https://jobs.opennash.com/companies/novartis/jobs/7ef2fdb237c30d76fe66/) ### [Lehre Mechatronik Mfd](https://jobs.opennash.com/companies/novartis/jobs/06e7215cb66fa85b6b5c/) ### [Lehre Elektrotechnik Mfd](https://jobs.opennash.com/companies/novartis/jobs/85e59ea199ac07765da7/) ### [Lehre Metalltechnik Mfd](https://jobs.opennash.com/companies/novartis/jobs/d8180e93182d35d5d352/) ### [Senior Expert Science Technology Downstream Process Development](https://jobs.opennash.com/companies/novartis/jobs/aaef7bb108bad3deb640/) ## Similar jobs at other companies ### [Automation Genesis - Process Automation Engineering Track](https://jobs.opennash.com/companies/siemens/jobs/93939e01add14a8b972b/) Siemens ### [Digital Industries Automation Internship Program - Process Automation Engineering Track](https://jobs.opennash.com/companies/siemens/jobs/59aa3e635d0d14694e9a/) Siemens ### [Test Automation Engineer](https://jobs.opennash.com/companies/accenture/jobs/c9909e14ff14518de605/) Accenture ### [endpoint automation engineer](https://jobs.opennash.com/companies/richemont/jobs/98fa7ed6b0c126f5bb14/) Richemont OpenNash lists jobs from employers’ own careers sites and does not handle applications. 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