[Skip to main content](#main-content) [OpenNash Jobs](https://jobs.opennash.com/) [Hiring report](/reports/hiring/) · [All Merck KGaA, Darmstadt, Germany and its affiliates jobs](https://jobs.opennash.com/companies/merck-kgaa-germany/) · [Search jobs](/search/) Merck KGaA, Darmstadt, Germany and its affiliates · Billerica, MA # Principal Scientist - In Vitro Immunotherapy Billerica, Massachusetts, United States Full-time Senior individual contributor $126,900 - $215,400 Research & Science Listed on Merck KGaA, Darmstadt, Germany and its affiliates’s official careers site. Posted October 13, 2026. Check that it is still open and apply there. [Apply on Merck KGaA, Darmstadt, Germany and its affiliates’s careers site →](https://careers.merckgroup.com/global/en/job/MQAMKDGLOBAL304607EXTERNALENGLOBAL/Principal-Scientist-In-Vitro-Immunotherapy) [OpenNash Jobs](https://jobs.opennash.com/) / [Merck KGaA, Darmstadt, Germany and its affiliates](https://jobs.opennash.com/companies/merck-kgaa-germany/) / Principal Scientist - In Vitro Immunotherapy ## Job description Work Your Magic with us! Start your next chapter and join EMD Serono. Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us. United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe. This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US. ### Your Role Help to shape next generation cancer immunotherapies at EMD Serono. As an In Vitro Principal Scientist, you will not only execute experiments but also lead and represent the in vitro strategy on discovery teams supporting Tumor Immunology projects. Our goal is to mobilize adaptive and innate immunity—spanning antibody therapeutics, T‑cell engagers, checkpoint modulators, and myeloid/NK activators—turning bold ideas into high‑quality clinical candidates in a fast‑paced, highly collaborative environment. ### Key Responsibilities - Provide creative, strategic input—conceive new project ideas and help design execution‑ready workplans - Drive early drug discovery projects in immuno-oncology by designing, conducting and overseeing in vitro/ex vivo pharmacology studies (human immune cell / tumor cell co‑culture assays; profile function via flow cytometry, cytokine/biomarker readouts, and high‑content imaging) to support development of novel biological and small molecule agents - Build and validate human immunology models that complement animal studies to improve translational predictivity and de‑risk candidates Scout, implement, and champion new assay platforms to investigate novel MOAs, boost data quality, throughput, and decision‑making speed Independently generate in vitro data for target selection, lead optimization, candidate nomination; and enable program decisions toward IND‑enabling studies - Analyze, document, and present results to multidisciplinary teams and senior leadership; manage studies at CROs and academic collaborations where needed ### Who You Are Minimum Qualifications: Bachelor’s degree with 8+ years of experience, or Master’s degree in Immunology, Cancer Immunology, Oncology, Molecular/Cell Biology, or other Science field with 5+ years of hands‑on immunology/immuno‑oncology (T‑cell biology) experience in academia or industry setting OR PhD in Immunology, Cancer Immunology, Oncology, Molecular/Cell Biology, or other Science field with 2+ years post‑PhD of hands‑on immunology/immuno‑oncology (T‑cell biology) experience in academia or industry setting. ### Preferred Qualifications Experience with driving early drug discovery projects and leading cross-functional teams, Expertise developing, running complex T‑cell functional assays (activation receptors, costimulatory molecules, checkpoint receptors) and interpreting mechanistic data to inform early development Experience in designing, executing, and interpreting in vitro assays for drug discovery, including tumor models and pharmacology experiments Clear, crisp communicator; highly organized multi-tasker who adapts quickly to deliver on‑time data packages Confident influencer who engages senior leadership and thrives in a matrixed organization Proven scientific impact—publications and contributions advancing new therapeutic concepts Pay Range for this position: $126,900 - $215,400 The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here. Direct link to benefits site if the hyperlink no longer works: [https://careers.emdgroup.com/us/en/benefits](https://careers.emdgroup.com/us/en/benefits) ]. ### What we offer We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress! Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity! ## At a glance - Posted by the employer: Oct 13, 2026 - First seen by OpenNash: Oct 19, 2026 - Last checked: Oct 19, 2026 - Listed for: 6 days - Location: Billerica, Massachusetts, United States - Employment type: Full-time - Pay: $126,900 - $215,400[Apply on Merck KGaA, Darmstadt, Germany and its affiliates’s careers site →](https://careers.merckgroup.com/global/en/job/MQAMKDGLOBAL304607EXTERNALENGLOBAL/Principal-Scientist-In-Vitro-Immunotherapy) ## More jobs at Merck KGaA, Darmstadt, Germany and its affiliates ### [Director, Real World Evidence Scientist (Oncology)](https://jobs.opennash.com/companies/merck-kgaa-germany/jobs/92900454e9a2e03ccaeb/) Billerica, Massachusetts, United States ### [Global Program Head non Oncology](https://jobs.opennash.com/companies/merck-kgaa-germany/jobs/f644d2b29c31288931de/) Billerica, Massachusetts, United States ### [Leader of Structure Biology and Protein Chemistry](https://jobs.opennash.com/companies/merck-kgaa-germany/jobs/ec2a4bdbf94b115a99d3/) Billerica, Massachusetts, United States ### [Research Development Quality Inspection Management Lead (GCP/GVP)](https://jobs.opennash.com/companies/merck-kgaa-germany/jobs/223935864ec403d8024a/) Billerica, Massachusetts, United States ### [Scientist Functional Genomics](https://jobs.opennash.com/companies/merck-kgaa-germany/jobs/3c214be1785a85b34943/) Billerica, Massachusetts, United States ## Similar jobs at other companies ### [Sr. Research Scientist, In Vitro DMB](https://jobs.opennash.com/companies/incyte/jobs/df4815fbf69e175dfda7/) Incyte · Wilmington, Delaware ### [Senior Associate Scientist, Neuroscience, In Vitro Pharmacology](https://jobs.opennash.com/companies/bristol-myers-squibb/jobs/189709a903f4e4c10995/) Bristol Myers Squibb · Cambridge Crossing - MA - US ### [Principal Scientist - Clinical and Scientist Affairs](https://jobs.opennash.com/companies/estee-lauder/jobs/43565c1b8fd39effa929/) The Estée Lauder Companies · Melville, NY, US, United States ### [Principal Applied Scientist](https://jobs.opennash.com/companies/microsoft/jobs/6887d8f40d7a9e34526e/) Microsoft · United States, Washington, Redmond OpenNash lists jobs from employers’ own careers sites and does not handle applications. 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