[Skip to main content](#main-content) [OpenNash Jobs](https://jobs.opennash.com/) [Hiring report](/reports/hiring/) · [All Eli Lilly jobs](https://jobs.opennash.com/companies/eli-lilly/) · [Search jobs](/search/) Eli Lilly · Lebanon, IN # MES Technical Lead / Systems Architect LP2 Lebanon, Indiana, United States of America Full-time Manager or lead $129,000 - $211,200 IT & Infrastructure Listed on Eli Lilly’s official careers site. Posted September 11, 2026. Check that it is still open and apply there. [Apply on Eli Lilly’s careers site →](https://careers.lilly.com/us/en/job/LILLUSR111232EXTERNALENUS/MES-Technical-Lead-Systems-Architect-LP2) [OpenNash Jobs](https://jobs.opennash.com/) / [Eli Lilly](https://jobs.opennash.com/companies/eli-lilly/) / MES Technical Lead / Systems Architect LP2 ## Job description At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. LP2 MES Technical Lead & Systems Architect — Lebanon, Indiana Lilly is building a new gene therapy manufacturing site (LP2) in Lebanon, Indiana. This role owns the Manufacturing Execution System (MES) end-to-end — from the Tulip application layer and Tulip Table data model, through MuleSoft integrations connecting SAP, QbDVision, and LabVantage, to the MQTT-based Unified Namespace driving real-time equipment communication. You will serve as both the technical authority over the platform’s architecture and the hands-on engineer responsible for its ongoing design, build, and validation. ### Key Responsibilities - Serve as Technical Lead/SME for LP2 MES architecture, design standards, and technical direction - Design, build, and validate Tulip applications for GxP manufacturing workflows and electronic batch records - Direct automation integrations with Automation Engineering (equipment commands, confirmations, process value subscriptions) Author/approve design specs ensuring compliance with ALCOA+ and 21 CFR Part 11 - Guide components through validated migration lifecycle (DEV → QA → Production) - Participate in Change Control Board (CCB) and ServiceNow change management - Partner with Manufacturing Operations, Automation Engineering, and Quality (BQA/CSQA) Mentor MES engineers; act as escalation point for complex issues - Collaborate with MES Product Owner on ALM requirements/backlog - Report system status and technical risk to site/IT leadership ### Basic Requirements Bachelor's degree in IT, Software /Computer Engineering or related field 5+ years with MES or pharma manufacturing IT platforms, including system integration (middleware/ERP/PLM) and Computer System Validation (CSV) in GMP settings Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1. Additional Skills /Preferences Modern software architecture and integration patterns MuleSoft/ Anypoint, DataWeave for MES–ERP(SAP)–PLM integrations MQTT, Unified Namespace (UNS), OPC UA knowledge CSV experience: Validation/Test Plans, IQ/OQ/UAT, design specs under 21 CFR Part 11/ALCOA+ Understanding of eBRs, non-terminal record controls, e-signatures Git/GitHub, GitHub Actions, MUnit, ALM/Jira - Familiarity with MABL and ServiceNow - Strong cross-functional communication and problem-solving skills Additional Information: Position Location: Lebanon, Indiana, with potential travel to other U.S. and global Lilly sites as required. ### Travel Percentage (%) Shift Information: Role is Monday through Friday and based on-site. Must be flexible in providing support to accommodate production schedules, batch execution windows, and change control activities. Occasional extended hours and/or off-hour support may be required. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( [https://careers.lilly.com/us/en/workplace-accommodation](https://careers.lilly.com/us/en/workplace-accommodation)) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL). Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $129,000 - $211,200 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. #WeAreLilly ## At a glance - Posted by the employer: Sep 11, 2026 - First seen by OpenNash: Oct 11, 2026 - Last checked: Oct 18, 2026 - Listed for: 37 days - Location: Lebanon, Indiana, United States of America - Employment type: Full-time - Pay: $129,000 - $211,200[Apply on Eli Lilly’s careers site →](https://careers.lilly.com/us/en/job/LILLUSR111232EXTERNALENUS/MES-Technical-Lead-Systems-Architect-LP2) ## More jobs at Eli Lilly ### [Advisor - Mixed Modality (Oligonucleotide) Scientist - Process Translation and Execution](https://jobs.opennash.com/companies/eli-lilly/jobs/05211858f5d516361492/) Lebanon, Indiana, United States of America ### [Advisor – Process Engineer. 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