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AstraZeneca · Mount Vernon, IN

# Senior Process Engineer

Mt. Vernon, Indiana, United States of America Full-time Senior individual contributor {'@type': 'MonetaryAmount', 'currency': '', 'value': {'@type': 'QuantitativeValue', 'unitText': ''}} Manufacturing & Production 

Listed on AstraZeneca’s official careers site. Posted October 14, 2026. Check that it is still open and apply there.
[Apply on AstraZeneca’s careers site →](https://careers.astrazeneca.com/job/mount-vernon/senior-process-engineer/7684/101964263504)

[OpenNash Jobs](https://jobs.opennash.com/) / [AstraZeneca](https://jobs.opennash.com/companies/astrazeneca/) / Senior Process Engineer

## Job description

Senior Process Engineer – Technical Operations Science & Innovation (TOSI), Band D Location – Mount Vernon, Indiana, U.S. AstraZeneca is a global, innovation-driven biopharmaceutical company. We focus on the discovery, development and delivery of life-changing medicines for patients, while working to minimize the environmental impact of our activities. We are proud of a culture that inspires innovation and collaboration, empowers colleagues to express diverse perspectives, and ensures that people feel valued and respected for their ideas and creativity.

At AstraZeneca, we are united by a common purpose: to push the boundaries of science to deliver life-changing medicines. Every single day, we make a difference by delivering potentially life-changing medicines to millions of people globally and by leading breakthrough science that promises to transform the treatment of disease. Our purpose is ambitious and so is our approach. Becoming a more agile and creative company means building a dynamic, inspiring culture where we celebrate diverse, bold thinking and act with a sense of urgency.

We are curious, creative, and open to new ideas and ways of working. We work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity, including in difficult situations, because we are committed to doing the right thing. We believe in the potential of our people and actively support colleagues to develop and achieve more than they thought possible. Technical Operations Science & Innovation (TOSI) provides scientific and engineering expertise to support the manufacture, continuous improvement, and lifecycle management of AstraZeneca products, working across internal manufacturing sites, external suppliers, and cross-functional product teams to strengthen process understanding, resolve technical challenges, and ensure reliable product supply.

This global role is based at AstraZeneca's strategic U.S. Oral Solid Dose manufacturing site, which also serves as a key hub for the introduction of new manufacturing technologies. What you can expect This role offers the opportunity to apply and broaden your experience in the technical support of commercial pharmaceutical products and manufacturing processes. You will work on real-world technical challenges that directly affect product supply, process robustness and lifecycle management.

You can expect to: Apply and extend your capability in mechanistic and physics-informed process modelling through relevant product and project work. Collaborate with experienced engineers and specialists in process engineering, materials science, PAT, data science, equipment engineering and pharmaceutical development. Translate physical understanding into mathematical descriptions, identify the data needed to test model assumptions, and apply models to support technical decisions.

Gain exposure to a broad range of products, manufacturing technologies and sites while working with internal teams and external partners. Take ownership of increasingly complex work packages and broaden your technical leadership responsibilities.

### Key Responsibilities

Provide process engineering support to a prioritized portfolio of commercial products manufactured at AstraZeneca sites and by external partners. Plan and deliver defined technical work packages, working with manufacturing sites and cross-functional specialists. Apply engineering fundamentals and structured problem-solving to understand manufacturing processes and resolve process or equipment-related issues. Develop and test mechanistic explanations of process behavior using calculations, experimental evidence and manufacturing data.

Develop and apply quantitative process descriptions, including mass and energy balances, scale-up relationships and, where appropriate, mechanistic or physics-informed models. Support product transfers, process changes and other activities that protect supply and improve manufacturing robustness. Communicate technical reasoning, assumptions, uncertainties and recommendations clearly in reports and discussions with stakeholders.

### Essential Skills and Experience

B.S./M.S. with at least three years of relevant experience in Chemical Engineering, Process Engineering, Mechanical Engineering, Applied Mathematics, Physics or another relevant quantitative discipline. Strong understanding of engineering or physical-science fundamentals and the ability to apply them to real processes. Evidence of curiosity about why processes behave as they do, with a structured approach to identifying and testing possible mechanisms.

Ability to analyze data quantitatively, make well-reasoned judgments and explain conclusions, assumptions and limitations clearly. Ability to plan and deliver technical work, collaborate effectively and develop new technical capabilities. Desirable

### Skills and Experience

PhD preferred Evidence of exploring a process, system or physical phenomenon mechanistically and expressing that understanding quantitatively. Experience using engineering calculations, mathematical models or simulations to understand or predict behavior. Experience designing experiments or analyzing data to test hypotheses, distinguish between mechanisms or estimate model parameters. Familiarity with a modelling or programming environment such as Python, MATLAB, gPROMS, DEM or equivalent tools.

Knowledge of relevant areas such as transport phenomena, particle or powder mechanics, residence-time behavior, population balances, scale-up or equipment–material interactions. Join us in building a new kind of organization and resetting expectations of what a biopharmaceutical company can be. If you are interested in applying engineering science to meaningful manufacturing challenges, we encourage you to apply. Date Posted 14-Oct-2026 Closing Date 05-Nov-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees.

In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

## At a glance
- Posted by the employer: Oct 14, 2026
- First seen by OpenNash: Oct 18, 2026
- Last checked: Oct 18, 2026
- Listed for: 4 days
- Location: Mt. Vernon, Indiana, United States of America
- Employment type: Full-time
- Pay: {'@type': 'MonetaryAmount', 'currency': '', 'value': {'@type': 'QuantitativeValue', 'unitText': ''}}[Apply on AstraZeneca’s careers site →](https://careers.astrazeneca.com/job/mount-vernon/senior-process-engineer/7684/101964263504)

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