[Skip to main content](#main-content) [OpenNash Jobs](https://jobs.opennash.com/) [Hiring report](/reports/hiring/) · [All Alphabet jobs](https://jobs.opennash.com/companies/alphabet/) · [Search jobs](/search/) Alphabet · South San Francisco, CA # Senior/Principal Associate Scientist, Mammalian Physiology South San Francisco, CA Senior individual contributor $130,000 - $161,000 Research & Science Listed on Alphabet’s official careers site. Posted October 20, 2026. Check that it is still open and apply there. [Apply on Alphabet’s careers site →](https://www.calicolabs.com/careers/?gh_jid=8904255002) [OpenNash Jobs](https://jobs.opennash.com/) / [Alphabet](https://jobs.opennash.com/companies/alphabet/) / Senior/Principal Associate Scientist, Mammalian Physiology ## Job description ### Who We Are Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. ### Position Description We are seeking a Senior/Principal Associate Scientist to join an interdisciplinary, collaborative team working at the intersection of mammalian stress response pathways and disease. The ideal candidate will be a skilled experimentalist with exceptional critical thinking skills, strong communication skills across cross-functional teams, and a strong history of productivity in fast-paced work environments. This person will be able to work both independently and collaboratively and will be detail-oriented, organized, adaptable and self-motivated. ### Key Responsibilities - Manage and coordinate in vivo studies, in collaboration with the Research Physiology team Independently conduct smaller in vivo studies Sample preparation and management and execution of downstream assays - Lead development and execution of primary cell culture assays Effectively communicate experimental results and project progress in various forums such as lab meetings Position Requirements: BS/MS degree in physiology, biology, genetics, neuroscience or a related field, with 8+ years (BS) or 6+ years (MS) of extensive experience with in vivo mammalian model systems - Proficiency in mammalian in vivo experiments and primary cell isolation and culture; familiarity with complex co-culture systems and/or organoids preferred Experienced in deploying biochemical, cellular and molecular assays, histology and immunofluorescence - Excellent written and oral communication skills and highly organized with ability to multi-task - Demonstrated ability to analyze and interpret complex data Versatile experimentalist with a track record of learning new skills quickly Skilled collaborator who is able to work closely with different teams to achieve project goals - Ability to independently plan, execute and analyze experiments to meet time-sensitive goals Basic statistical skills required Preference for prior experience working with data software such as Prism - Must be willing to work on site 5 days a week The estimated base salary range for this role is $130,000 - $161,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses. ## At a glance - Posted by the employer: Oct 20, 2026 - First seen by OpenNash: Oct 23, 2026 - Last checked: Oct 23, 2026 - Listed for: 3 days - Location: South San Francisco, CA - Pay: $130,000 - $161,000[Apply on Alphabet’s careers site →](https://www.calicolabs.com/careers/?gh_jid=8904255002) ## More jobs at Alphabet ### [Postdoctoral Fellow, Nile Lab - Ubiquitin/UBL Chemical Biology](https://jobs.opennash.com/companies/alphabet/jobs/a695ce664774208c460a/) South San Francisco, CA ### [Principal Scientist, DMPK](https://jobs.opennash.com/companies/alphabet/jobs/cb2b544f0e41ab2e8978/) South San Francisco, CA ### [Principal Scientist, Peptide Chemistry](https://jobs.opennash.com/companies/alphabet/jobs/993d2871ef17166535e4/) South San Francisco, CA ### [Principal Scientist, Process Chemistry](https://jobs.opennash.com/companies/alphabet/jobs/b825da67c30a8db86fee/) South San Francisco, CA ### [Scientist, Peptide Chemistry](https://jobs.opennash.com/companies/alphabet/jobs/507409189054f1c52b4e/) South San Francisco, CA ## Similar jobs at other companies ### [Principal Scientist - Clinical and Scientist Affairs](https://jobs.opennash.com/companies/estee-lauder/jobs/43565c1b8fd39effa929/) The Estée Lauder Companies · Melville, NY, US, United States ### [Principal Applied Scientist](https://jobs.opennash.com/companies/microsoft/jobs/6887d8f40d7a9e34526e/) Microsoft · United States, Washington, Redmond ### [Principal, Data Scientist - Applied Machine Learning](https://jobs.opennash.com/companies/walmart/jobs/8af78490b17976e76747/) Walmart · United States ### [Oligo Discovery Process Chemistry Principal Scientist](https://jobs.opennash.com/companies/gsk/jobs/0fe209490f5fe151a4a7/) GSK · Cambridge, Massachusetts, United States of America OpenNash lists jobs from employers’ own careers sites and does not handle applications. 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