[Skip to main content](#main-content) [OpenNash Jobs](https://jobs.opennash.com/) [Hiring report](/reports/hiring/) · [All Alphabet jobs](https://jobs.opennash.com/companies/alphabet/) · [Search jobs](/search/) Alphabet · South San Francisco, CA # Senior / Staff Machine Learning Research Engineer South San Francisco, CA Senior individual contributor $220,000 - $290,000 Data & Analytics Listed on Alphabet’s official careers site. Posted May 5, 2026. Check that it is still open and apply there. [Apply on Alphabet’s careers site →](https://www.calicolabs.com/careers/?gh_jid=8457339002) [OpenNash Jobs](https://jobs.opennash.com/) / [Alphabet](https://jobs.opennash.com/companies/alphabet/) / Senior / Staff Machine Learning Research Engineer ## Job description Senior / Staff Machine Learning Research Engineer Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. ### Position Description Calico seeks Machine Learning Research Engineers to join our rapidly growing ML team. You will play a critical role establishing the engineering culture for frontier ML research in drug discovery. You will bring a high level of engineering rigor to our machine learning efforts and accelerate our research maturing into tangible clinical and product impact. This will be a high agency role designed for a builder who wants to operate as a founding member of a new functional group. ### Please note No biology or life sciences background is required for this role. ### Position Responsibilities You will drive the engineering vision behind our machine learning models, from identifying high-impact ML research opportunities to delivering production-grade systems. Partnering closely with biology-fluent ML researchers and Data Engineers, your responsibilities will span the following areas: Advance Foundational ML Capabilities: - Translate new ideas and prototype models (e.g., diffusion networks, vision transformers, and DNA sequence models) into highly-optimized and scalable JAX or PyTorch code on accelerators Dive deep into model architectures to optimize training and inference performance, implementing advanced strategies such as model parallelism Research Engineering: Proactively identify emerging engineering gaps required for expanding our research capabilities Architect solutions for complex systems challenges, such as asynchronous execution, hardware orchestration, and high-throughput data pipelines - Build foundational libraries that enforce software engineering rigor Force Multiplier: Design and implement evaluation frameworks, benchmarks, and scientific workflow tools that accelerate the company’s whole research lifecycle and allow the team to rapidly test promising ideas Position Requirements: A strong intellectual curiosity for life sciences BS/MS with 7+ years or PhD with 4+ years of relevant experience Expertise in Python and JAX or PyTorch - Track record of building, training, or optimizing advanced ML architectures (e.g., transformers, diffusion networks, GNNs) from concept to publication or production - Must be willing to work onsite at least four days a week Nice to Have: Experience working with biological, medical, or chemistry datasets Contributions to open-source ML projects or first-author ML publications Experience training models across distributed systems and optimizing performance Experience with cloud infrastructure (e.g., GCP, Kubernetes, Docker) Advanced degree in computer science The estimated base salary range for this role is $220,000 - $290,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses. ## At a glance - Posted by the employer: May 5, 2026 - First seen by OpenNash: Aug 20, 2026 - Last checked: Oct 23, 2026 - Listed for: 171 days - Location: South San Francisco, CA - Pay: $220,000 - $290,000[Apply on Alphabet’s careers site →](https://www.calicolabs.com/careers/?gh_jid=8457339002) ## More jobs at Alphabet ### [Associate Director/Director, Biostatistics](https://jobs.opennash.com/companies/alphabet/jobs/b4418901fe9b7ba55f9b/) South San Francisco, CA ### [Machine Learning Scientist / Senior Machine Learning Scientist](https://jobs.opennash.com/companies/alphabet/jobs/3e1e36a5d96b16ef3d6a/) South San Francisco, CA ### [Associate Director, Medical Writing](https://jobs.opennash.com/companies/alphabet/jobs/608486a2adacbcdd1805/) South San Francisco, CA ### [Associate Director/Director, Contracts and Alliances](https://jobs.opennash.com/companies/alphabet/jobs/d26ad4c3dfc3b75d7aa1/) South San Francisco, CA ### [Director, Accounting](https://jobs.opennash.com/companies/alphabet/jobs/343faa2afe02f55efbf0/) South San Francisco, CA ## Similar jobs at other companies ### [Research Intern - Machine Learning for Biology and Healthcare](https://jobs.opennash.com/companies/microsoft/jobs/726db5a4d5e1cfbdd4bb/) Microsoft · United States, Massachusetts, Cambridge ### [Research Intern - Machine Learning and Statistics](https://jobs.opennash.com/companies/microsoft/jobs/6d9f9818afff6249a01a/) Microsoft · United States, Massachusetts, Cambridge, Washington, Redmond ### [AI Machine Learning Engineering Staff](https://jobs.opennash.com/companies/lockheed-martin/jobs/a50fa89c9d061673bf86/) Lockheed Martin · Virtual Three, TX ### [Senior Staff Engineer, Machine Learning Engineering ( On-device Learning SW)](https://jobs.opennash.com/companies/qualcomm/jobs/d561df305202050c72d5/) Qualcomm · San Diego, California, United States of America ### [A/AI Machine Learning Engineering Staff - Clearance Required](https://jobs.opennash.com/companies/lockheed-martin/jobs/fee14b837ea19e8438a2/) Lockheed Martin · Huntsville, AL OpenNash lists jobs from employers’ own careers sites and does not handle applications. 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