[Skip to main content](#main-content) [OpenNash Jobs](https://jobs.opennash.com/) [Hiring report](/reports/hiring/) · [All Alnylam Pharmaceuticals jobs](https://jobs.opennash.com/companies/alnylam-pharmaceuticals/) · [Search jobs](/search/) Alnylam Pharmaceuticals · United States # Manager, Site and Monitoring Health Lead United States Manager or lead $123,300 — $166,800 Listed on Alnylam Pharmaceuticals’s official careers site. Posted September 16, 2026. Check that it is still open and apply there. [Apply on Alnylam Pharmaceuticals’s careers site →](https://job-boards.greenhouse.io/alnylampharmaceuticals/jobs/4400210009) [OpenNash Jobs](https://jobs.opennash.com/) / [Alnylam Pharmaceuticals](https://jobs.opennash.com/companies/alnylam-pharmaceuticals/) / Manager, Site and Monitoring Health Lead ## Job description ### Overview The Site and Monitoring Health Lead (SMH Lead) will apply knowledge of regulations and GCPs as well as experience in monitoring to safeguard the quality of clinical trial execution at investigator sites and ensure Alnylam’s oversight of CRO monitoring effectiveness. This is a site-facing position that reports to the Associate Director, Site and Monitoring Health or above. ### Key Responsibilities - Implement Alnylam’s Site and Monitoring Health strategy in alignment with ICH GCP E6 and E8 Employ risk-based thinking to focus on what is critical to quality, and exhibit an “inspection ready at all times” mentality Create Study Specific Oversight Plans (SSOP) for aligned trials in scope and/or follow SSOP when conducting oversight activities - Implement various types of oversight encounters and activities as applicable including but not limited to: site risk analysis, site contacts, aggregate review of data, monitoring visit report review, Sponsor Oversight Visits, system/data spot checks, and periodic summaries; ensure timely documentation of these activities is completed and filed - Build relationships with investigators and site staff in region; act as a resource for identifying potential sites for new studies - Utilize root cause analysis to assess identified issues and provide suggested actions to Study Management / CRO to mitigate risk - Support investigator sites less experienced in research; assist in assuring sites are engaged in the study and have what they need to recruit participants successfully - Troubleshoot and use alternative and innovative approaches to solve problems impacting clinical site delivery and quality - Work closely with Clinical Risk & Analytics staff to understand the risk management plan (Risk MAP) for assigned studies, ensure the SSOP is aligned with the Risk MAP, and assess sites who are outliers - Lead oversight and trend meetings with the study team and/or CRO to discuss risks, issues, and trends identified by the SMH team for the trial - Complete administrative tasks (e.g., timesheets, expense reports, Sponsor Oversight Visit reports, etc.) consistently on time and with good quality - Work independently and collaboratively with cross-functional teams - Support inspection preparation and management - Maintain awareness of changes in industry and regulatory standards for GCP requirements Travel on assignment is required since this is a site facing position. In general, Qualifications Bachelor's Degree is required. A clinical or advanced degree (e.g. RN, MPH, MS, MA, MBA, PharmD) is preferred Previous direct monitoring experience gained with a CRO or pharmaceutical company working on multinational clinical studies; Lead CRA/management experience preferred Experience in all study phases of clinical research (Phase I-III; experience in both prevalent and rare medical conditions preferred Previous audit support and regulatory inspection experience preferred Comprehensive and current regulatory knowledge, including GCPs - Demonstrate flexibility in schedule and willingness to travel frequently in assigned region - Excellent interpersonal, verbal, and written communication skills Fluency in multiple languages and cultural awareness is a plus - Ability to build and maintain relationships with key investigators and sites (e.g. key networks, key trial sites and investigators, key opinion leaders and their site staff Innovator, willing to initiate changes, introduce new ideas, and creatively problem-solve Experience with Microsoft based applications and ability to learn internal and external computer systems Good organizational skills and ability to deal with competing priorities - Analyze complex situations and effectively communicate issues along with potential recommendations to various functional groups - Demonstrate good judgment and decision-making experience About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. Before applying, please review Alnylam's ⁠Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment. The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: [https://www.alnylam.com/careers](https://www.alnylam.com/careers) U.S. Pay Range $123,300 — $166,800 USD ## At a glance - Posted by the employer: Sep 16, 2026 - First seen by OpenNash: Nov 3, 2026 - Last checked: Nov 3, 2026 - Listed for: 48 days - Location: United States - Pay: $123,300 — $166,800[Apply on Alnylam Pharmaceuticals’s careers site →](https://job-boards.greenhouse.io/alnylampharmaceuticals/jobs/4400210009) ## Hiring at Alnylam Pharmaceuticals - Open jobs: 102 - New in the last 7 days: After two weekly collections - Tracked since: Oct 20, 2026 [All Alnylam Pharmaceuticals jobs](https://jobs.opennash.com/companies/alnylam-pharmaceuticals/) · [Weekly hiring report](/reports/hiring/) ## More jobs at Alnylam Pharmaceuticals ### [Associate Dir, Health Systems, Medical Outcomes Science Liaison (North Central-Chicago)](https://jobs.opennash.com/companies/alnylam-pharmaceuticals/jobs/1ad3ef860db22613fefb/) United States ### [Associate Director, Biostatistics](https://jobs.opennash.com/companies/alnylam-pharmaceuticals/jobs/60386718d847d4f68880/) United States ### [Associate Director, Clinical Pharmacology](https://jobs.opennash.com/companies/alnylam-pharmaceuticals/jobs/8f913dceb22b60b06e69/) United States ### [Associate Director, Field Operations](https://jobs.opennash.com/companies/alnylam-pharmaceuticals/jobs/c21412362ea763dc9a2b/) United States ### [Associate Director, Field Reimbursement](https://jobs.opennash.com/companies/alnylam-pharmaceuticals/jobs/f4e5156f36706bae0f3e/) United States ## Similar jobs at other companies ### [Senior Site Reliability Developer- Oracle Health](https://jobs.opennash.com/companies/oracle/jobs/72374eeda666e4835175/) Oracle · United States ### [(USA) 1st Shift Coordinator, Patient Care - Health And Wellness Non-Store Operations (On-site Call Center)](https://jobs.opennash.com/companies/walmart/jobs/f3745545779049c3b147/) Walmart · United States ### [Lead Software Engineer - Observability & Platform Health Monitoring](https://jobs.opennash.com/companies/jpmorganchase/jobs/5fbfb06dfba7244df02a/) JPMorganChase · Columbus, OH, United States ### [Principal Condition Monitoring Engineer – Power Generation - Data Center Infrastructure (on-site Nashville, TN)](https://jobs.opennash.com/companies/oracle/jobs/afeaae0095f6b7bc8b25/) Oracle · Nashville, TN, United States ### [Site Management and Monitoring Hub Head (oncology)](https://jobs.opennash.com/companies/astrazeneca/jobs/b2302858bb8a4ef98c78/) AstraZeneca · Wilmington, Delaware OpenNash lists jobs from employers’ own careers sites and does not handle applications. Dates come from the employer where stated; “first seen” and “last checked” are our own observations. OpenNash Jobs · Official listings with dates and links to the employer. [Weekly hiring report](/reports/hiring/) · [Methodology](/methodology/)