[Skip to main content](#main-content) [OpenNash Jobs](https://jobs.opennash.com/) [Hiring report](/reports/hiring/) · [All AbbVie jobs](https://jobs.opennash.com/companies/abbvie/) · [Search jobs](/search/) AbbVie # Senior Scientist I Ii Computational Hitgen Leadgen In North Chicago Il Jid 33479 Senior individual contributor Research & Science Listed on AbbVie’s official careers site. Listed as of October 18, 2026. Check that it is still open and apply there. [Apply on AbbVie’s careers site →](https://careers.abbvie.com/en/job/senior-scientist-i-ii-computational-hitgen-leadgen-in-north-chicago-il-jid-33479) [OpenNash Jobs](https://jobs.opennash.com/) / [AbbVie](https://jobs.opennash.com/companies/abbvie/) / Senior Scientist I Ii Computational Hitgen Leadgen In North Chicago Il Jid 33479 ## Job description Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube. ### Job Description Purpose: This position brings an opportunity to make innovative contributions that will define how AbbVie leverages AI-enabled drug discovery across our small molecule portfolio. The key responsibilities of this position are to identify, develop, optimize, validate, and deploy innovative methods for computational hit generation. This role will collaborate closely with project teams comprising medicinal chemists, structural biologists, biochemists, cell biologists, and other computational chemistry / chemoinformatics experts. ### Responsibilities - Consult with project team to establish desirable project-relevant hit/lead criteria - Develop and maintain proficiency with the collection of cutting-edge computational methods available to the HGLG team Support project teams by decisively identifying the method(s) that best fit the project goals, and deploying the most suitable method(s) for the task at hand Effectively communicate to the project team the rationale for chosen methodologies, explaining how these approaches are optimally suited to the task and how they inform the resulting designs for a given target - Contribute to development of methods / workflows for computational hit generation, including methods to predict binding affinities of diverse chemotypes, to design compounds with specified pharmacological properties (PK parameters, etc.), and to rapidly sample both enumerated and AI-generated chemical spaces. Computational methods to evaluate / optimize synthetic tractability of designs from generative AI are of particular interest for this role. ### Qualifications Senior Scientist I: Degree in relevant field (chemistry / computer science / machine learning / cheminformatics / chemical engineering) with experience developing machine learning models related to chemical and biological data (10+ years of experience for BS, 8+ years for MS, 0+ years for PhD) ### Senior Scientist II Degree in relevant field (chemistry / computer science / machine learning / cheminformatics / chemical engineering) with experience developing machine learning models related to chemical and biological data (12+ years of experience for BS, 10+ years for MS, 4+ years for PhD) - Knowledge and experience in modern computational approaches for medicinal chemistry Expertise using cutting-edge computational approaches built on Machine Learning/Deep learning and Cheminformatics - Ability to implement, debug, and maintain computational tools in common programming languages (e.g., Python) - Familiarity with AI/ML-enabled molecular generation, pose prediction, affinity prediction and/or prediction of pharmacological properties (e.g. PK) Familarity with retrosynthetic analysis, to contribute to refining workflows for generation/prioritization of novel molecules on the basis of synthetic tractability - Strong analytical and problem-solving skills with demonstrated ability to think critically and creatively, and provide solutions both individually and collaboratively with internal experts - Excellent ability to communicate clearly and concisely with colleagues and collaborators including an ability to explain complex ideas to non-specialists Preferred: has contributed to molecular design in an early-stage drug discovery campaign (hit gen / lead gen) Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​ The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​ We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​ This job is eligible to participate in our long-term incentive programs. ### Note No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.​ AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit [https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html](https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html) US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: [https://www.abbvie.com/join-us/reasonable-accommodations.html](https://www.abbvie.com/join-us/reasonable-accommodations.html) ## At a glance - Posted by the employer: Not stated - First seen by OpenNash: Oct 11, 2026 - Last checked: Oct 18, 2026 - Listed for: 7 days[Apply on AbbVie’s careers site →](https://careers.abbvie.com/en/job/senior-scientist-i-ii-computational-hitgen-leadgen-in-north-chicago-il-jid-33479) ## More jobs at AbbVie ### [Associate Director Principal Scientist I Precision Medicine Immunology In Waltham Ma Jid 33691](https://jobs.opennash.com/companies/abbvie/jobs/ffdfd3f4c1a23435c0fd/) ### [Associate Scientist Ii And Scientist I Labormitarbeiter Durchfuehrung Von Zellulaeren Und Binde Assa In Ludwigshafen Rp Jid 33925](https://jobs.opennash.com/companies/abbvie/jobs/33e65efbfb1162d356fd/) ### [Associate Scientist Ii In Worcester Ma Jid 32109](https://jobs.opennash.com/companies/abbvie/jobs/7ea82b7e858a1ae6ffd8/) ### [Associate Scientist Ii Scientist I Chemical Biology And Mass Spectrometry Technologies In North Chicago Il Jid 32701](https://jobs.opennash.com/companies/abbvie/jobs/b7d8fd9fab86c3a076a2/) ### [Associate Scientist Ii Scientist I Predictive Stability In North Chicago Il Jid 33510](https://jobs.opennash.com/companies/abbvie/jobs/3c8b062a51881a345245/) ## Similar jobs at other companies ### [AI/ML Computational Scientist](https://jobs.opennash.com/companies/accenture/jobs/b88bc852615d8b5d4930/) Accenture ### [AI/ML Computational Science Analyst](https://jobs.opennash.com/companies/accenture/jobs/383ce0fcf28c81d9d440/) Accenture ### [PhD Position: AI-driven computational models for battery degradation](https://jobs.opennash.com/companies/siemens/jobs/7008382eb9fe3105a52e/) Siemens ### [Computational Geometry Engineer](https://jobs.opennash.com/companies/siemens-energy/jobs/be6ac075803746cebbcc/) Siemens Energy ### [Associate Director or Senior Scientist, Computational Chemistry, Research](https://jobs.opennash.com/companies/takeda-pharmaceutical/jobs/693b175318e7692c4999/) Takeda Pharmaceutical OpenNash lists jobs from employers’ own careers sites and does not handle applications. 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