[Skip to main content](#main-content) [ OpenNash ](https://opennash.com/) / [Jobs](https://jobs.opennash.com/) [ 01 Search jobs](https://jobs.opennash.com/search/)[ 02 Companies](https://jobs.opennash.com/explore/)[ 03 Hiring report](https://jobs.opennash.com/reports/hiring/)[ 04 AI assistants](https://jobs.opennash.com/connect/)[ 05 How it works](https://jobs.opennash.com/methodology/) AbbVie # Principal Research Scientist I Sirna Platform Automation In Worcester Ma Jid 34638 Senior individual contributor Research & Science Listed on AbbVie’s official careers site. Listed as of November 1, 2026. Check that it is still open and apply there. [Apply on AbbVie’s careers site →](https://careers.abbvie.com/en/job/principal-research-scientist-i-sirna-platform-automation-in-worcester-ma-jid-34638) [OpenNash Jobs](https://jobs.opennash.com/) / [AbbVie](https://jobs.opennash.com/companies/abbvie/) / Principal Research Scientist I Sirna Platform Automation In Worcester Ma Jid 34638 ## Job description Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube. ### Job Description AbbVie’s Biotherapeutics and Genetic Medicine (BGM) department is seeking a highly motivated Principal Research Scientist to join our expanding siRNA team. In this role, you will partner with genetic medicine teams to establish a high-throughput siRNA screening platform that advances pipeline innovation through next-generation delivery modalities and supports the discovery of therapeutic leads across multiple disease areas. ### Responsibilities Establish and implement a high-throughput siRNA screening platform using automated liquid-handling systems. Serve as a subject matter expert in siRNA screening experimental design, execution, and data interpretation. Lead research efforts and mentor scientists to advance siRNA optimization, including sequence design and novel chemical modifications, across multiple programs. Generate new scientific hypotheses and proposals, improve existing screening workflows, and evaluate emerging technologies in the siRNA field. Communicate clearly and effectively with internal siRNA teams and cross-functional collaborators to identify needs and support platform enhancement and program advancement. Manage and develop a team of at least 2-3 scientists, providing technical guidance, mentorship, and day-to-day leadership to support program goals. ### Qualifications BS, MS, or PhD in Molecular Biology, Biochemistry, Chemical Biology, or a related field, with typically 6+ years (PhD), 12+ years (MS), or 14+ years (BS) of relevant experience in biotech or pharma. Proven track record in siRNA design, in vitro screening, and potency assays with experience using automated high-throughput platforms (e.g., Hamilton, Tecan). Experience with assays including, but not limited to, qRT-PCR, ELISA, and flow cytometry. Demonstrated experience in cell culture, including the maintenance of diverse cell lines. Prior experience leading siRNA platform initiatives or portfolio programs. Exceptional interpersonal skills and the ability to build productive working relationships with diverse internal teams and external collaborators. Strong track record of presenting complex scientific data to internal and external stakeholders. Experience in animal study design and downstream assays to evaluate genetic medicines is a plus. Prior people management experience is a plus. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​ The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​ We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​ This job is eligible to participate in our short-tern and long-term incentive programs. ​ Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.​ AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit [https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html](https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html) US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: [https://www.abbvie.com/join-us/reasonable-accommodations.html](https://www.abbvie.com/join-us/reasonable-accommodations.html) ## At a glance - Posted by the employer: Not stated - First seen by OpenNash: Oct 25, 2026 - Last checked: Nov 1, 2026 - Listed for: 7 days[Apply on AbbVie’s careers site →](https://careers.abbvie.com/en/job/principal-research-scientist-i-sirna-platform-automation-in-worcester-ma-jid-34638) ## More jobs at AbbVie ### [2027 Synthetic Chemistry Intern Phd In North Chicago Il Jid 34808](https://jobs.opennash.com/companies/abbvie/jobs/b5fa4cfd9aef1d047daf/) ### [Associate Director Principal Scientist I Precision Medicine Immunology In Waltham Ma Jid 33691](https://jobs.opennash.com/companies/abbvie/jobs/ffdfd3f4c1a23435c0fd/) ### [Associate Scientist Ii And Scientist I Labormitarbeiter Durchfuehrung Von Zellulaeren Und Binde Assa In Ludwigshafen Rp Jid 33925](https://jobs.opennash.com/companies/abbvie/jobs/33e65efbfb1162d356fd/) ### [Associate Scientist Ii In Worcester Ma Jid 32109](https://jobs.opennash.com/companies/abbvie/jobs/7ea82b7e858a1ae6ffd8/) ### [Associate Scientist Ii Scientist I Analytical Validation Team In North Chicago Il Jid 34465](https://jobs.opennash.com/companies/abbvie/jobs/856f44e606b7d6720bd6/) ## Similar jobs at other companies ### [Senior Research Scientist – Physical AI (f/m/d)](https://jobs.opennash.com/companies/siemens/jobs/84458293d5e6c073590f/) Siemens ### [Research Principal Scientist](https://jobs.opennash.com/companies/waters/jobs/6e0723e05d61fd9b1c51/) Waters ### [西门子中国研究院 具身大模型科学家 Expert Research Scientist on Autonomous Polyfunctional Robots (Foundation Models)](https://jobs.opennash.com/companies/siemens/jobs/b53a76fc0531f3c652f7/) Siemens ### [Associate Principal Scientist Professional Skincare Management Application Domain L Oreal Research](https://jobs.opennash.com/companies/loreal/jobs/538ca5610504d4ad456f/) L'Oréal ### [Kanagawa Embodied Ai Research Scientist 14](https://jobs.opennash.com/companies/fujitsu/jobs/9b5913e5cdc779e0a3e9/) Fujitsu OpenNash lists jobs from employers’ own careers sites and does not handle applications. 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